C14orf169 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD217743A
Immunohistochemistry of paraffin-embedded Human lung cancer tissue using C14orf169 Polyclonal Antibody at dilution of 1:45(×200)
Product Name
C14orf169 Polyclonal Antibody
Catalog Number
RD217743A
Clonality
Polyclonal
Purification Method
Antigen affinity purification
Isotype
IgG
Host
Rabbit
Background
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation.
Immunogen Information
Immunogen
Synthetic peptide of human C14orf169
Swissprot
Q9H6W3
Synonyms
60S ribosomal protein L8 histidine hydroxylaseC14orf169Chromosome 14 open reading frame 169Histone lysine demethylase NO66hsNO66Hypothetical protein FLJ21802Lysine-specific demethylase NO66MAPJDMYC associated protein with JmjC domainNO66NO66Nu
Gene Accession
NP078920
Applications
Reactivity
Human, Mouse, Rat
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:30-1:150, ELISA 1:5000-1:10000
Concentration
0.8 mg/mL
Storage Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas