CAB39 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD79153A
Western Blot analysis of Lovo cell using CAB39 Polyclonal Antibody at dilution of 1:200
Immunohistochemistry of paraffin-embedded Human brain using CAB39 Polyclonal Antibody at dilution of 1:40
Immunohistochemistry of paraffin-embedded Human liver cancer using CAB39 Polyclonal Antibody at dilution of 1:40
Product Name
CAB39 Polyclonal Antibody
Catalog Number
RD79153A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
Peutz-Jeghers Syndrome (PJS) is a rare hereditary disease characterized by melanocytic macules of the lips, gastrointestinal hamartomatous polyps and an increased risk for many classes of cancer. The serine/threonine kinase LKB1 (also designated STK11) has been identified as the gene mutated in PJS. LKB1 activity increases upon the binding of a regulatory complex consisting of the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase and the calcium binding protein 39 (MO25 alpha). STRAD and MO25 determine the subcellular localization of LKB1 by initiating its translocation from the nucleus to the cytoplasm, thus regulating the tumor suppressor activity of LKB1. The LKB1/STRAD/MO25 complex acts as an AMP-activated protein kinase kinase (AMPKK).
Immunogen Information
Immunogen
Synthetic peptide of human CAB39
Swissprot
Q9Y376
Synonyms
Cab39CAB39Calcium binding protein 39Calcium-binding protein 39CGI 66CGI-66CGI66MO25 alphaMO25Mouse protein 25 alphaProtein Mo25
Calculated MW
40 kDa
Gene Accession
NP_057373
Applications
Reactivity
Human,Mouse
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:50-1:200
Concentration
0.7 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas