CACNA2D2 Polyclonal Antibody

For reference only. Please follow the manual included in your kit for instructions.

Catalog Number
RD217757A
Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue  using CACNA2D2 Polyclonal Antibody at dilution of 1:45(×200)
Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CACNA2D2 Polyclonal Antibody at dilution of 1:45(×200)
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Overview

Circle
Product Name
CACNA2D2 Polyclonal Antibody
Catalog Number
RD217757A
Clonality
Polyclonal
Purification Method
Antigen affinity purification
Isotype
IgG
Host
Rabbit

Background

Circle
Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms.

Immunogen Information

Circle
Immunogen
Synthetic peptide of human CACNA2D2
Swissprot
Q9NY47
Synonyms
Alpha 2 delta calcium channel subunitCA2D2CACNA2DCacna2d2Calcium channelvoltage-dependentalpha 2/delta subunit 2Calcium channelvoltage-dependentalpha 2/delta subunit 2 gene 26Calcium voltage gated channel auxiliary subunit alpha2delta 2Gene 26
Gene Accession
NP001167522

Applications

Circle
Reactivity
Human, Mouse, Rat
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:30-1:150, ELISA 1:5000-1:10000
Concentration
0.7 mg/mL
Storage Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.

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