Calpains are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. Calpain families have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. Calpain I and II are heterodimeric with distinct large subunits associated with common small subunits, all of which are encoded by different genes. This gene encodes a small subunit common to both calpain I and II and is associated with myotonic dystrophy. Two transcript variants encoding the same protein have been identified for this gene.
Immunogen Information
Immunogen
Recombinant protein of human CAPNS1
Swissprot
P04632
Synonyms
30KCalcium activated neutral proteinaseCalcium activated neutral proteinase small subunitCalcium dependent protease small subunit 1Calcium dependent protease small subunitCalcium-activated neutral proteinase small subunitCalcium-dependent protease s
Calculated MW
28 kDa
Gene Accession
BC000592
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:50-1:200
Concentration
0.3 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4