CARD16 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD217810A
Western blot analysis of Human placenta tissue lysate using CARD16 Polyclonal Antibody at dilution of 1:800
Immunohistochemistry of paraffin-embedded Human liver cancer tissue using CARD16 Polyclonal Antibody at dilution of 1:55(×200)
Product Name
CARD16 Polyclonal Antibody
Catalog Number
RD217810A
Clonality
Polyclonal
Purification Method
Antigen affinity purification
Isotype
IgG
Host
Rabbit
Background
Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.
Immunogen Information
Immunogen
Synthetic peptide of human CARD16
Swissprot
Q5EG05
Synonyms
CAR16CARD only domain-containing protein 1CARD only proteinCARD16Caspase recruitment domain familymember 16Caspase recruitment domain-containing protein 16Caspase-1 dominant-negative inhibitor pseudo-ICECaspase-1 inhibitor COPCOPCOP1Pseudo i
Calculated MW
23 kDa
Observed MW
Refer to figures
Gene Accession
NP001017534
Applications
Reactivity
Human
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:40-1:200, ELISA 1:5000-1:10000
Concentration
1.1 mg/mL
Storage Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas