This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Immunogen Information
Immunogen
Recombinant protein of human CASP10
Swissprot
Q92851
Synonyms
ALPS2Apoptotic protease Mch-4CASP 10CASP-10CASP10CASPACaspase 10 apoptosis related cysteine peptidaseCaspase-10 subunit p12FADD like ICE2Fas associated death domain proteinFAS-associated death domain protein interleukin-1B-converting enzyme 2FL
Gene Accession
BC042844
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:25-1:100
Concentration
0.2 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4