CASP3 Monoclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD85639A
Immunohistochemistry of paraffin-embedded Human skin tissue using CASP3 Monoclonal Antibody at dilution of 1:200.
Immunohistochemistry of paraffin-embedded Human prostate tissue using CASP3 Monoclonal Antibody at dilution of 1:200.
Product Name
CASP3 Monoclonal Antibody
Catalog Number
RD85639A
Clonality
Monoclonal
Purification Method
Protein A purification
Isotype
IgG
Host
Mouse
Background
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.
Immunogen Information
Immunogen
Synthetic Peptide of Caspase-3
Swissprot
P42574
Synonyms
A830040C14RikApopainCASP-3CASP3CASP3Casp3aCaspase 3Caspase 3apoptosis-related cysteine peptidaseCaspase 3apoptosis-related cysteine proteaseCaspase 3apoptosis-related cysteine protease aCaspase-3 subunit p12CC3CPP-32CPP32CPP32BCysteine p
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
IHC-p
Conjugation
Unconjugated
Dilution
IHC 1:100-200
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas