CASP3 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
Immunohistochemistry analysis of paraffin-embedded A549 in Human breast using CASP3 Polyclonal Antibody at dilution of 1:400.
Immunohistochemistry analysis of paraffin-embedded A549 in Mouse lung using CASP3 Polyclonal Antibody at dilution of 1:400.
Immunohistochemistry analysis of paraffin-embedded A549 in Mouse Subcutaneous tumor using CASP3 Polyclonal Antibody at dilution of 1:400.
Product Name
CASP3 Polyclonal Antibody
Catalog Number
RD70575A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
Caspases, a family of endoproteases, are critical players in cell regulatory networks controlling inflammation and cell death. Initiator caspases (caspase-2, -8, -9, -10, -11, and -12) cleave and activate downstream effector caspases (caspase-3, -6, and -7), which in turn execute apoptosis by cleaving targeted cellular proteins. Caspase 3 (also named CPP32, SCA-1, and Apopain) proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at the beginning of apoptosis. Caspase 3 plays a key role in the activation of sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Caspase 3 can also form heterocomplex with other proteins and performs MW of 50-70 kDa. This antibody can recognize p17, p19 and p32 of Caspase 3.
Immunogen Information
Immunogen
KLH conjugated Synthetic peptide corresponding to Mouse caspase3
Swissprot
P70677,P42574,P55213
Synonyms
A830040C14RikApopainCASP-3CASP3CASP3Casp3aCaspase 3Caspase 3apoptosis-related cysteine peptidaseCaspase 3apoptosis-related cysteine proteaseCaspase 3apoptosis-related cysteine protease aCaspase-3 subunit p12CC3CPP-32CPP32CPP32BCysteine p
Applications
Research Areas