This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade. Alternative splicing results in two transcript variants which encode different isoforms.
Immunogen Information
Immunogen
Synthetic peptide of human CASP9 (active)
Swissprot
P55211
Synonyms
APAF-3APAF3Apoptosis related cysteine peptidaseApoptotic protease Mch-6Apoptotic protease-activating factor 3CASP-9CASP9CASP9Caspase 9 apoptosis related cysteine peptidaseCaspase 9 Dominant NegativeCaspase 9cCaspase-9Caspase-9 subunit p10ICE
Gene Accession
NP_001220
Applications
Reactivity
Human,Mouse
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:100-1:300
Concentration
0.5 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4