The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene.
Immunogen Information
Immunogen
Recombinant protein of human CTSB
Swissprot
P07858
Synonyms
Amyloid precursor protein secretaseAPP secretaseAPPSCATBCathepsin B heavy chainCathepsin B1CathepsinBCPSBCTSBcysteine proteaseOTTHUMP00000116009OTTHUMP00000229510OTTHUMP00000229511OTTHUMP00000229512OTTHUMP00000229514OTTHUMP00000229515OTTHU
Gene Accession
BC010240
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:150-1:500
Concentration
0.8 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4