Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene.
Immunogen Information
Immunogen
Synthetic peptide of human CACNA1D
Swissprot
Q01668
Synonyms
alpha-1 polypeptideCAC1DCACH3CACN4CACNA 1DCacna1dCACNL1A2Calcium channelCalcium channel L type alpha 1 polypeptide isoform 2Calcium channel neuroendocrine/brain type alpha 1 subunitCalcium channel voltage dependent L type alpha 1Calcium channel
Gene Accession
NP_001122312
Applications
Reactivity
Human,Rat
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.7 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4