May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway.
Immunogen Information
Immunogen
Synthesized peptide derived from the C-terminal region of human Caveolin-1
Swissprot
Q03135
Synonyms
BSCL3CAVCAV1CAV1caveolae protein22 kDcaveolin 1 alpha isoformcaveolin 1 beta isoformCaveolin 1 caveolae protein 22kDaCaveolin-1Caveolin1cell growth-inhibiting protein 32CGL3LCCNSMSTP085OTTHUMP00000025031PPH3VIP 21VIP21
Calculated MW
20 kDa
Observed MW
25 kDa
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC-p,IF,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-2000, IHC 1:50-300, IF 1:50-300
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4