CBFA2T2 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
Immunohistochemistry of paraffin-embedded Human breast cancer tissue using CBFA2T2 Polyclonal Antibody at dilution of 1:60(×200)
Product Name
CBFA2T2 Polyclonal Antibody
Catalog Number
RD252991A
Clonality
Polyclonal
Purification Method
Antigen affinity purification
Isotype
IgG
Host
Rabbit
Background
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.
Immunogen Information
Immunogen
Fusion protein of human CBFA2T2
Swissprot
O43439
Synonyms
AML1 MTG8cbfa2t2Core binding factor runt domain alpha subunit 2 translocated to 2core-binding factorrunt domainalpha subunit 2DKFZp313F2116EHTETO homolog on chromosome 20ETO homologous on chromosome 20MTG 8 like proteinMTG 8 related protein 1
Gene Accession
BC040344
Applications
Reactivity
Human, Mouse
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:300, ELISA 1:5000-1:10000
Concentration
1.08 mg/mL
Storage Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.