CBFA2T2 Polyclonal Antibody

For reference only. Please follow the manual included in your kit for instructions.

Catalog Number
RD252991A
Immunohistochemistry of paraffin-embedded Human breast cancer tissue  using CBFA2T2 Polyclonal Antibody at dilution of 1:60(×200)
Immunohistochemistry of paraffin-embedded Human breast cancer tissue using CBFA2T2 Polyclonal Antibody at dilution of 1:60(×200)
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Overview

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Product Name
CBFA2T2 Polyclonal Antibody
Catalog Number
RD252991A
Clonality
Polyclonal
Purification Method
Antigen affinity purification
Isotype
IgG
Host
Rabbit

Background

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In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.

Immunogen Information

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Immunogen
Fusion protein of human CBFA2T2
Swissprot
O43439
Synonyms
AML1 MTG8cbfa2t2Core binding factor runt domain alpha subunit 2 translocated to 2core-binding factorrunt domainalpha subunit 2DKFZp313F2116EHTETO homolog on chromosome 20ETO homologous on chromosome 20MTG 8 like proteinMTG 8 related protein 1
Gene Accession
BC040344

Applications

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Reactivity
Human, Mouse
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:300, ELISA 1:5000-1:10000
Concentration
1.08 mg/mL
Storage Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.

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