This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder
Immunogen Information
Immunogen
Synthetic peptide of human CBL
Swissprot
P22681
Synonyms
4732447J05RikC CBLCas Br M (murine) ecotropic retroviral transforming sequenceCasitas B lineage lymphoma proto oncogeneCasitas B-lineage lymphoma proto-oncogeneCBL 2cblCBLCBL2E3 ubiquitin protein ligase CBLE3 ubiquitin-protein ligase CBLOncogen
Calculated MW
100 kDa
Gene Accession
NP_005179
Applications
Reactivity
Human,Mouse
Tested Applications
WB,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
0.3 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4