This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.
Immunogen Information
Immunogen
Recombinant protein corresponding to Mouse MCP-1
Swissprot
P13500,P10148
Synonyms
C-C motif chemokine 2CCL2CCL2Chemokine (C C motif) ligand 2GDCF 2GDCF-2GDCF2HC11HSMCR30JEMCAFMCP 1MCP-1MCP1MGC9434Monocyte chemoattractant protein 1Monocyte chemotactic and activating factorMonocyte chemotactic protein 1Monocyte secretor
Applications
Reactivity
Human,Mouse
Tested Applications
IHC
Conjugation
Unconjugated
Dilution
IHC 1:200-1:800
Concentration
490 μg/mL
Storage Buffer
PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4