This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19).
Immunogen Information
Immunogen
Recombinant protein of human CCL21
Swissprot
O00585
Synonyms
6CkineBeta-chemokine exodus-2C C motif chemokine ligand 21C-C motif chemokine 21CCL21CCL21Chemokine (C-C motif) ligand 21Chemokine CC motif ligand 21CKb9ECLEfficient Chemoattractant for LymphocytesSCYA21Secondary lymphoid-tissue chemokineSLC
Gene Accession
BC027918
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.5 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4