This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene.
Immunogen Information
Immunogen
Synthesized peptide derived from the N-terminal region of human CD133.
Swissprot
O43490
Synonyms
AC133Antigen AC133CD133CORD12Hematopoietic stem cell antigenhPromininMCDR2MSTP061OTTHUMP00000217744OTTHUMP00000217745OTTHUMP00000217746PROM1PROM1Prominin IProminin like 1Prominin like protein 1 precursorProminin mouse like 1Prominin-1Pro
Calculated MW
97 kDa
Observed MW
100 kDa
Applications
Reactivity
Human,Mouse
Tested Applications
WB,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, ELISA 1:20000
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4