This gene is ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. May be play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.
Immunogen Information
Immunogen
Synthetic peptide of human ICOSLG
Swissprot
O75144
Synonyms
B7 H2B7 homolog 2B7 homologue 2B7 like protein Gl50B7 related protein 1B7-H2B7-like protein Gl50B7-related protein 1B7H2B7RP 1B7RP-1B7RP1CD 275CD275CD275 antigenGL 50GL50ICOS LICOS LGICOS ligandICOSLICOSLIcoslgInducible T cell co st
Gene Accession
NP_056074.1
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:25-1:100
Concentration
0.3 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4