TLR4,also named as CD284,belongs to the Toll-like receptor family. TLR4 cooperates with LY96 and CD14 to mediates the innate immune response to bacterial lipopolysaccharide (LPS). TLR4 acts via MYD88,TIRAP and TRAF6,leading to NF-kappa-B activation,cytokine secretion and the inflammatory response. Three alternatively spliced transcript variants that encode different protein isoforms have been described.
Immunogen Information
Immunogen
KLH conjugated Synthetic peptide corresponding to Mouse TLR4
Swissprot
O00206,Q9QUK6,Q9QX05
Synonyms
ARMD10CD284CD284 antigenHomolog of Drosophila tollhTollTLR 4TLR4TLR4TOLLToll like receptor 4Toll-like receptor 4
Applications
Reactivity
Human,Rat
Tested Applications
IHC
Conjugation
Unconjugated
Dilution
IHC 1:200-1:800
Concentration
1.1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4