CDC123 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD217737A
Western blot analysis of 293T and Hela cell lysates using CDC123 Polyclonal Antibody at dilution of 1:550
Product Name
CDC123 Polyclonal Antibody
Catalog Number
RD217737A
Clonality
Polyclonal
Purification Method
Antigen affinity purification
Isotype
IgG
Host
Rabbit
Background
The eukaryotic cell division cycle consists of a number of gene-controlled sequences that involve cyclin dependent kinases (Cdks) and cell division control (Cdc) proteins. Cdc123 (Cell division cycle protein 123), also known as D123, is a 336 amino acid cytoplasmic protein that is involved in cell cycle control. Widely expressed with high expression in thymus, spleen, ovary, testis, small intestine and leukocytes, Cdc123 functions to destabilize Chfr (checkpoint with forkhead and ring finger domain) proteins which, when accumulated, block the G to S phase transition. Cdc123 prevents the Chfr proteins from collecting in the cell, thereby allowing the cell to enter the S phase. Due to its role in cell cycle control, Cdc123 is thought to be a basal marker for luminal breast cancers.
Immunogen Information
Immunogen
Synthetic peptide of human CDC123
Swissprot
O75794
Synonyms
C10orf7CD123CDC123Cell division cycle 123Cell division cycle 123 homologCell division cycle protein 123 homologD123HT 1080HT-1080Protein D123PZ32
Calculated MW
39 kDa
Observed MW
Refer to figures
Gene Accession
NP006014
Applications
Reactivity
Human, Mouse, Rat
Tested Applications
WB,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, ELISA 1:5000-1:10000
Concentration
0.9 mg/mL
Storage Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas