The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction.
Immunogen Information
Immunogen
Synthetic peptide of human CDC27
Swissprot
P30260
Synonyms
ANAPC3Anaphase Promoting Complex 3Anaphase promoting complex protein 3Anaphase Promoting Complex Subunit 3Anaphase-promoting complex subunit 3APC 3APC3Cdc 27Cdc27CDC27 homologCDC27CDC27HsCell Division Cycle 27Cell division cycle protein 27 ho
Calculated MW
92 kDa
Gene Accession
NP_001107563
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:25-1:100
Concentration
0.3 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4