This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.
Immunogen Information
Immunogen
Synthetic peptide of human CDH12
Swissprot
P55289
Synonyms
Br cadherinBR-cadherinBrain cadherinCAD12_HUMANcadherin 12 (N cadherin 2)Cadherin 12Cadherin 12 precursorCadherin 12 type 2 (N cadherin 2)Cadherin 12 type 2Cadherin neural type 2Cadherin-12CDH12CDHBFLJ34857N cadherin 2N-cadherin 2Neural ty