CDK4 Polyclonal Antibody

For reference only. Please follow the manual included in your kit for instructions.

Catalog Number
RD70310A
Immunohistochemistry analysis of paraffin-embedded human stomach cancer  using CDK4 Polyclonal Antibody at dilution of 1:100.
Immunohistochemistry analysis of paraffin-embedded human stomach cancer using CDK4 Polyclonal Antibody at dilution of 1:100.
Immunohistochemistry analysis of paraffin-embedded human breast  using CDK4 Polyclonal Antibody at dilution of 1:100.
Immunohistochemistry analysis of paraffin-embedded human breast using CDK4 Polyclonal Antibody at dilution of 1:100.
Immunohistochemistry analysis of paraffin-embedded human colon  using CDK4 Polyclonal Antibody at dilution of 1:100.
Immunohistochemistry analysis of paraffin-embedded human colon using CDK4 Polyclonal Antibody at dilution of 1:100.
Immunohistochemistry analysis of paraffin-embedded rat ovary  using CDK4 Polyclonal Antibody at dilution of 1:100.
Immunohistochemistry analysis of paraffin-embedded rat ovary using CDK4 Polyclonal Antibody at dilution of 1:100.
Immunohistochemistry analysis of paraffin-embedded rat testis  using CDK4 Polyclonal Antibody at dilution of 1:100.
Immunohistochemistry analysis of paraffin-embedded rat testis using CDK4 Polyclonal Antibody at dilution of 1:100.
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Overview

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Product Name
CDK4 Polyclonal Antibody
Catalog Number
RD70310A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit

Background

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The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.

Immunogen Information

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Immunogen
KLH conjugated Synthetic peptide corresponding to Mouse CDK4
Swissprot
P11802,P30285,P35426
Synonyms
Cdk 4cdk4CDK4 proteinCDK4Cell division kinase 4Cell division protein kinase 4CMM 3CMM3Crk3Cyclin dependent kinase 4Cyclin-dependent kinase 4Melanoma cutaneous malignant 3MGC14458p34 cdk4PSK J3PSK-J3

Applications

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Reactivity
Human,Rat
Tested Applications
IHC
Conjugation
Unconjugated
Dilution
IHC 1:100
Concentration
210 μg/mL
Storage Buffer
PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.

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