CDKN2AIP Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD75301A
Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CDKN2AIP Polyclonal Antibody at dilution 1:40
Variation
Quantity
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Overview
Product Name
CDKN2AIP Polyclonal Antibody
Catalog Number
RD75301A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
CDKN2AIP (CDKN2A-interacting protein), also known as CARF, is a 580 amino acid protein that activates p53 via p14 ARF (alternate reading frame)-dependent and independent pathways. CDKN2AIP-dependent activation of p53, a protein that up-regulates growth arrest and apoptosis-related genes in response to stress signals, leads to an enhancement of p53 function. Expression levels of CDKN2AIP and p53 show an inverse relationship that is caused by a negative-feedback control via a proteasome-mediated degradation pathway. CDKN2AIP is expressed ubiquitously across tissue samples and, along with p14 ARF, is localized to the perinucleolar region within the nucleus.
Immunogen Information
Immunogen
Recombinant protein of human CDKN2AIP
Swissprot
Q9NXV6
Synonyms
Calcium response factorCARFCARFCDKN2A interacting proteinCDKN2A-interacting proteinCdkn2aipcollaborates/cooperates with ARF (alternate reading frame) proteinCollaborator of ARFFLJ20036
Gene Accession
BC022270
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.3 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas