The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.
Immunogen Information
Immunogen
Synthetic peptide of human CELSR2
Swissprot
Q9HCU4
Synonyms
Cadherin EGF LAG seven pass G type receptor 2 flamingo Drosophila homologCadherin EGF LAG seven-pass G-type receptor 2Cadherin family member 10CDHF10CELR2Celsr2EGF like domain multiple 2EGF-like protein 2EGFL2epidermal growth factor like 2Epider
Gene Accession
NP_001399
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.4 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4