CEMIP Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD252102A
Immunohistochemistry of paraffin-embedded Human liver cancer tissue using CEMIP Polyclonal Antibody at dilution of 1:60(×200)
Product Name
CEMIP Polyclonal Antibody
Catalog Number
RD252102A
Clonality
Polyclonal
Purification Method
Antigen affinity purification
Isotype
IgG
Host
Rabbit
Background
Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing.
Immunogen Information
Immunogen
Synthetic peptide of human CEMIP
Swissprot
Q8WUJ3
Synonyms
IR2155535KIAA1199 proteinOTTHUMP00000185569OTTHUMP00000195036TMEM2LTransmembrane protein 2 like
Gene Accession
NP061159
Applications
Reactivity
Human, Mouse
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200, ELISA 1:5000-1:10000
Concentration
0.78 mg/mL
Storage Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas