This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease.
Immunogen Information
Immunogen
Synthetic peptide of human CENPF
Swissprot
P49454
Synonyms
AH antigenCell cycle dependent 350K nuclear proteinCENFCENP FCENP F kinetochore proteinCENP-FCENPFCENPF kinetochore proteinCENPFCentromere protein F 350/400kaCentromere protein FCentromere protein F350/400kDaCILD31Hcp 1Hcp1Kinetochore prot
Gene Accession
NP_057427
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.4 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4