CERS4 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD76936A
Western Blot analysis of Human fetal liver tissue, HT-29 and HUVEC cell, MCF-7 cell and Human hepatocellular carcinoma tissue using CERS4 Polyclonal Antibody at dilution of 1:300
Immunohistochemistry of paraffin-embedded Human ovarian cancer using CERS4 Polyclonal Antibody at dilution of 1:35
Immunohistochemistry of paraffin-embedded Human prostate cancer using CERS4 Polyclonal Antibody at dilution of 1:35
Variation
Quantity
For more information on our kits, please contact us at info@reddotbiotech.com
Overview
Product Name
CERS4 Polyclonal Antibody
Catalog Number
RD76936A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
The LASS (longevity assurance homolog) family members are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1, LASS2, LASS3, LASS4, LASS5 and LASS6) and they are all involved in sphingolipid synthesis. LASS4 is a 394 amino acid endoplasmic reticulum, multi-pass membrane protein. LASS4 increases the levels of long ceramides such as C22:0- and C24:0-ceramides. In cells deficient for CLN9, as observed in neuronal ceroid lipofuscinosis (NCL) or Batten disease, LASS4 can increase ceramide levels and partially correct growth and apoptosis.
Immunogen Information
Immunogen
Synthetic peptide of human CERS4
Swissprot
Q9HA82
Synonyms
ceramide synthase 4CerS4FLJ12089LAG1 homolog ceramide synthase 4LAG1 longevity assurance homolog 4LAG1S. cerevisiaehomolog of4LASS 4LASS4LASS4 LAG1 homolog ceramide synthase 4LASS4TRAM homolog 1Trh 1Trh1
Calculated MW
46 kDa
Gene Accession
NP_078828
Applications
Reactivity
Human
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:50-1:200
Concentration
0.9 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas