The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus.
Immunogen Information
Immunogen
Synthetic peptide of human KRT16
Swissprot
P08779
Synonyms
CK 16CK-16CK16Cytokeratin-16Cytokeratin16FNEPPKFocal non epidermolytic palmoplantar keratodermaK 16K16K1C16K1CPKeratin 1 type IKeratin 16KeratinKeratin type I cytoskeletal 16Keratin-16Keratin16KRT 16Krt16KRT16ANEPPKPC1type I cytoskel
Calculated MW
51 kDa
Gene Accession
NP_005548
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:50-1:200
Concentration
0.6 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4