This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene.
Immunogen Information
Immunogen
Recombinant protein of human KRT8
Swissprot
P05787
Synonyms
CARD2CK 8CK-8CK8CYK8CYKERCytokeratin endo ACytokeratin-8DreK8EndoAK2C8K2C8K8Keratin 8Keratin type II cytoskeletal 8Keratintype II cytoskeletal 8Keratin-8KOKrt 2.8KRT8MGC118110MGC174782MGC53564MGC85764sb:cb186Type-II keratin Kb8
Gene Accession
BC008200
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.6 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4