Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.
Immunogen Information
Immunogen
Synthetic peptide of human CLDN1
Swissprot
O95832
Synonyms
Claudin-1Claudin1CLD 1CLD1CLD1CLDN 1Cldn1ILVASCSEMP 1SEMP1Senescence associated epithelial membrane protein 1Senescence associated epithelial membrane proteinSenescence-associated epithelial membrane protein
Calculated MW
23 kDa
Gene Accession
NP_066924
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:1000-1:3000, IHC 1:100-1:300
Concentration
0.5 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4