Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat.
Immunogen Information
Immunogen
Synthetic peptide of human CLDN3
Swissprot
O15551
Synonyms
C7orf1Claudin-3Claudin3CLD3CLDN 3Cldn3Clostridium perfringens enterotoxin receptor 2CPE R2CPE receptor 2CPE-R 2CPE-receptor 2CPETR 2CPETR2HRVP 1HRVP1Rat ventral prostate 1 like proteinRat ventral prostate.1 protein homologRVP1Ventral pro
Calculated MW
23 kDa
Gene Accession
NP_001297
Applications
Reactivity
Human
Tested Applications
WB,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
0.4 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4