CLDND1 (claudin domain containing 1), also known as C3orf4 or HSPC174, is a 253 amino acid multi-pass membrane protein that is expressed at high levels in adult brain and at lower levels in adult heart. Existing as two alternatively spliced isoforms, CLDND1 is encoded by a gene that maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. Key tumor suppressing genes on chromosome 3 include those that encode the apoptosis mediator RASSF1, the cell migration regulator HYAL1 and the angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3.
Immunogen Information
Immunogen
Recombinant protein of human CLDND1
Swissprot
Q9NY35
Synonyms
C3orf4Chromosome 3 open reading frame 4Claudin domain containing 1Claudin domain containing 1 proteinGENX 3745Membrane protein GENX3745MGC111162MGC3316MGC9861OTTHUMP00000217407OTTHUMP00000217408OTTHUMP00000217423OTTHUMP00000217424OTTHUMP00000
Gene Accession
BC001757
Applications
Reactivity
Human,Mouse
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.2 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4