Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it.
Immunogen Information
Immunogen
Recombinant Protein
Swissprot
P13073
Synonyms
AL024441COX 4COX IV 1COX IVCOX IV-1Cox4COX41Cox4aCOX4BCOX4I1COX4I2COX4L2COXIVCytochrome c oxidase polypeptide IVCytochrome c oxidase subunit 4 isoform 1 mitochondrialCytochrome c oxidase subunit 4 isoform 1mitochondrialCytochrome C Oxidas
Calculated MW
20 kDa
Observed MW
15 kDa
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC-p,IF
Conjugation
Unconjugated
Dilution
WB 1:1000-3000, IHC 1:50-300, IF 1:100-1:300
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.4.