Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer of proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Va of the human mitochondrial respiratory chain enzyme. A pseudogene COX5AP1 has been found in chromosome 14q22.
Immunogen Information
Immunogen
Synthetic peptide of human COX5A
Swissprot
P20674
Synonyms
COXCOX VACOX5ACOX5ACytochrome c oxidase polypeptide VaCytochrome c oxidase polypeptidemitochondrialCytochrome c oxidase subunit 5ACytochrome c oxidase subunit 5AmitochondrialCytochrome c oxidase subunit VamitochondrialMitochondrial cytochrome
Gene Accession
NP_004246
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.3 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4