CRACR2A Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD219269A
Immunohistochemistry of paraffin-embedded Human brain tissue using CRACR2A Polyclonal Antibody at dilution of 1:60(×200)
Product Name
CRACR2A Polyclonal Antibody
Catalog Number
RD219269A
Clonality
Polyclonal
Purification Method
Antigen affinity purification
Isotype
IgG
Host
Rabbit
Background
Ca2+-binding protein that plays a key role in store-operated Ca2+entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca2+resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
Immunogen Information
Immunogen
Fusion protein of human CRACR2A
Swissprot
Q9BSW2
Synonyms
Calcium release-activated calcium channel regulator 2ACRAC channel regulator 2ACRACR2AEF hand calcium binding domain 4BEF hand calcium binding domain containing protein 4BEF-hand calcium-binding domain-containing protein 4BEFC4BEFCAB 4BEfcab4bFLJ
Gene Accession
BC004524
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200, ELISA 1:5000-1:10000
Concentration
0.84 mg/mL
Storage Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas