Ca2+-binding protein that plays a key role in store-operated Ca2+entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca2+resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
Immunogen Information
Immunogen
Fusion protein of human CRACR2A
Swissprot
Q9BSW2
Synonyms
Calcium release-activated calcium channel regulator 2ACRAC channel regulator 2ACRACR2AEF hand calcium binding domain 4BEF hand calcium binding domain containing protein 4BEF-hand calcium-binding domain-containing protein 4BEFC4BEFCAB 4BEfcab4bFLJ