CTNNA1 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD75101A
Western Blot analysis of A431 cell using CTNNA1 Polyclonal Antibody at dilution of 1:600
Immunohistochemistry of paraffin-embedded Human gastic cancer using CTNNA1 Polyclonal Antibody at dilution of 1:35
Product Name
CTNNA1 Polyclonal Antibody
Catalog Number
RD75101A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
Catenin alpha-1is aproteinthat in humans is encoded by theCTNNA1gene. Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be mucHuman, Mouseore dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components.
Immunogen Information
Immunogen
Recombinant protein of human CTNNA1
Swissprot
P35221
Synonyms
Alpha E-cateninCadherin associated protein 102kDaCadherin associated proteinCadherin-associated proteinCAP 102CAP102Catenin (cadherin associated protein) alpha 1 102kDaCatenin (cadherin associated protein)alpha 1102kDaCatenin alpha 1Catenin alp
Calculated MW
100 kDa
Gene Accession
BC031262
Applications
Reactivity
Human,Mouse
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:50-1:200
Concentration
0.2 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas