CXCL12/SDF1 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD86664A
Western blotting with anti-CXCL12 polyclonal antibody at dilution of 1:2000. Lane 1: THP-1 cell lysate, lane 2: Raw264.7 cell lysate, lane 3: K562 cell lysate for negative control.
Western blot of Rat testis with CXCL4 polyclonal antibody at 1:1000 dilution.
Product Name
CXCL12/SDF1 Polyclonal Antibody
Catalog Number
RD86664A
Clonality
Polyclonal
Purification Method
Antigen affinity purification
Isotype
IgG
Host
Rabbit
Background
The stromal cell derived factor 1 (SDF1/CXCL12) is a small, pro-inflammatory chemoattractant cytokine that regulates leukocyte trafficking through interactions with its cognate 7-transmembrane G protein-coupled receptors. The SDF1/CXCL12 receptor, CXCR4, also serves as a coreceptor for the entry of human immunodeficiency virus into target cells. SDF1/CXCL12 may regulate homing and maintenance of CXCR4-expressing stem or progenitor cells, including embryonic and many somatic stem cells. Many cancer cells express CXCR4, suggesting that SDF1/CXCL12 plays a role in cancer metastasis. Alternative splicing and differential processing during maturation produce a pair of SDF1/CXCL12 isoforms (SDF1/CXCL12α and SDF1/CXCL12β) that have different properties and biological activities. Additional isoforms of SDF1/CXCL12 have been reported.
Immunogen Information
Immunogen
Recombinant Rat CXCL12 protein expressed by E.coli.
Gene ID
24772
Swissprot
Q9QZD1
Synonyms
Cxcl12SDF-1
Calculated MW
14kDa
Observed MW
18kDa
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB
Conjugation
Unconjugated
Dilution
WB 1:2000-1:4000
Concentration
1mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol,pH 7.4
Storage Instructions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Research Areas