This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.
Immunogen Information
Immunogen
Recombinant protein of human CYP1A1
Swissprot
P04798
Synonyms
AHHAHRRAryl hydrocarbon hydroxylaseCP11CP1A1CYP 1CYP1cyp1a1CYPIA1Cytochrome P1 450 dioxin inducibleCytochrome P1-450Cytochrome P450 1A1Cytochrome P450 family 1 subfamily A polypeptide 1Cytochrome P450 form 6Cytochrome P450 subfamily I (aroma
Calculated MW
58 kDa
Observed MW
Refer to figures
Gene Accession
BC023019
Applications
Reactivity
Human
,Mouse
,Rat
Tested Applications
WB,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
0.3 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4