This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region.
Immunogen Information
Immunogen
Synthetic peptide of human CYP1A2
Swissprot
P05177
Synonyms
Aryl hydrocarbon hydroxylaseCP 12CP12CP1A2CYP1A2CYPIA2Cytochrome P(3)450Cytochrome P450 1A2Cytochrome P450 4Cytochrome P450 family 1 polypeptide 2Cytochrome P450 family 1 subfamily A polypeptide 2Cytochrome P450 subfamily I aromatic compound in
Calculated MW
58 kDa
Gene Accession
NP_000752
Applications
Reactivity
Human
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:200-1:1000, IHC 1:50-1:200
Concentration
0.3 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4