This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Immunogen Information
Immunogen
Recombinant protein of human DAB2
Swissprot
P98082
Synonyms
DAB 2Dabmitogen-responsive phosphoproteinhomolog 2 (Drosophila)DAB2Differentially expressed in ovarian cancer 2Differentially expressed protein 2Disabled (Drosophila) homolog 2 (mitogen responsive phosphoprotein)Disabled homolog 2Disabled homolog
Calculated MW
82 kDa
Gene Accession
BC003064
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:50-1:200
Concentration
0.6 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4