DCAMKL1/DCLK1 Polyclonal Antibody

For reference only. Please follow the manual included in your kit for instructions.

Catalog Number
RD88581A
Western blot analysis of extracts of various cell lines using DCAMKL1/DCAMKL1/DCLK1 Polyclonal Antibody at 1:1000 dilution.
Western blot analysis of extracts of various cell lines using DCAMKL1/DCAMKL1/DCLK1 Polyclonal Antibody at 1:1000 dilution.
Variation
Quantity
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Overview
Circle
Product Name
DCAMKL1/DCLK1 Polyclonal Antibody
Catalog Number
RD88581A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
Circle
This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.
Immunogen Information
Circle
Immunogen
Recombinant fusion protein of human DCAMKL1/DCAMKL1/DCLK1
Gene ID
9201
Swissprot
O15075
Synonyms
DCLK1CL1CLICK1DCAMKL1DCDC3ADCLK
Calculated MW
69kDa/70kDa
Observed MW
80kDa
Applications
Circle
Reactivity
Human,Mouse
Tested Applications
WB
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
1mg/mL
Storage Buffer
PBS with 0.01% thiomersal,50% glycerol,pH7.3.
Storage Instructions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Research Areas
Circle

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