This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
Immunogen Information
Immunogen
Synthetic peptide of human DCC
Swissprot
P43146
Synonyms
Colorectal cancer related chromosome sequence 18Colorectal cancer suppressorCRC 18CRC18CRCR 1CRCR1DCCDCCDeleted in colorectal cancer proteinDeleted in colorectal carcinomaImmunoglobulin superfamily DCC subclass member 1Netrin receptor DCCTumor
Gene Accession
NP_005206
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.7 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4