DCUN1D1 Polyclonal Antibody

For reference only. Please follow the manual included in your kit for instructions.

Catalog Number
RD87940A
Western blot analysis of extracts of various cell lines using DCUN1D1 Polyclonal Antibody at 1:1000 dilution.
Western blot analysis of extracts of various cell lines using DCUN1D1 Polyclonal Antibody at 1:1000 dilution.
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Overview

Circle
Product Name
DCUN1D1 Polyclonal Antibody
Catalog Number
RD87940A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit

Background

Circle
Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8 thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity.

Immunogen Information

Circle
Immunogen
Recombinant fusion protein of human DCUN1D1
Gene ID
54165
Swissprot
Q96GG9
Synonyms
DCUN1D1DCNL1DCUN1L1RP42SCCROSCROTes3
Calculated MW
23kDa
Observed MW
24KDa

Applications

Circle
Reactivity
Human,Mouse
Tested Applications
WB
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
1mg/mL
Storage Buffer
PBS with 0.01% thiomersal,50% glycerol,pH7.3.
Storage Instructions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

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