DDB1 Polyclonal Antibody

For reference only. Please follow the manual included in your kit for instructions.

Catalog Number
RD82971A
Western blot analysis of extracts of various cell lines using DDB1 Polyclonal Antibody at dilution of 1:3000.
Western blot analysis of extracts of various cell lines using DDB1 Polyclonal Antibody at dilution of 1:3000.
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For more information on our kits, please contact us at info@reddotbiotech.com

Overview

Circle
Product Name
DDB1 Polyclonal Antibody
Catalog Number
RD82971A
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit

Background

Circle
The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins.

Immunogen Information

Circle
Immunogen
A synthetic peptide of human DDB1 (NP_001914.3).
Gene ID
1642
Swissprot
Q16531
Synonyms
DDB1DDBAUV-DDB1XAP1XPCEXPEXPE-BF
Calculated MW
50 kDa/126 kDa
Observed MW
127 kDa

Applications

Circle
Reactivity
Human,Mouse,Rat
Tested Applications
WB
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.

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