This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Four alternatively spliced transcript variants have been described for this gene, with two of them encoding different isoforms and the other two probably not encoding a protein. Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed.
Immunogen Information
Immunogen
Recombinant protein of human DIABLO
Swissprot
Q9NR28
Synonyms
0610041G12RikDBLOHDBOHDFNA64diabloDiablo homolog (Drosophila)Diablo homologDiablo homolog mitochondrialDiablo IAP binding mitochondrial proteinDiablo like proteinDIABLO SDirect IAP binding protein with low pIDirect IAP-binding protein with low
Calculated MW
27 kDa
Gene Accession
BC011909
Applications
Reactivity
Human,Mouse
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:1000-1:5000, IHC 1:50-1:200
Concentration
0.4 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4