The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms.
Immunogen Information
Immunogen
Synthetic peptide of human DIO2
Swissprot
Q92813
Synonyms
5DIID2Deiodinaseiodothyroninetype IIDIO2DIOIIEC 1.97.1.10IOD2ITDI2SelYThyroxine deiodinasetype IITXDI2Type 2 DIType 2 iodothyronine deiodinaseType II 5' deiodinaseType II iodothyronine deiodinaseType-II 5''-deiodinase
Gene Accession
NP_000784
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:25-1:100
Concentration
0.9 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4