This gene encodes a protein with multiple coiled coil motifs which is located in the Nucleus, Cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Immunogen Information
Immunogen
Synthetic peptide of human DISC1
Swissprot
Q9NRI5
Synonyms
C1orf136DISC1DISC1Disrupted in schizophrenia 1Disrupted in schizophrenia 1 proteinKIAA0457RP4-730B13.1SCZD9
Gene Accession
NP_061132
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.4 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4