This gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity.
Immunogen Information
Immunogen
Fusion protein of human DLK1
Swissprot
P80370
Synonyms
Adipocyte differentiation inhibitor proteinBrevideltinDelta like 1 homologDelta like homologDelta like proteinDelta1DLK 1DLKDLK-1DLK1DLK1FA 1FA1Fetal antigen 1pG2Preadipocyte factor 1Pref 1PrefPref1Protein delta homolog 1SecredeltinZO