This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants.
Immunogen Information
Immunogen
Recombinant protein of human LIG1
Swissprot
P18858
Synonyms
DNA ligase 1DNA ligase IDNLI1LIG 1lig1Ligase I DNA ATP dependentMGC117397MGC130025Polydeoxyribonucleotide synthase [ATP] 1
Gene Accession
BC110622
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:100-1:300
Concentration
1 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4